Memory formation influenced by brain network development in young age: Study

Washington [US], February 19 (ANI): A recent study of direct brain recordings in children and adolescents discovered that as brains matured, the precise ways by which two key memory regions in the brain communicate made us better at forming lasting memories.
The study was conducted by a Northwestern Medicine scientist and colleagues from Wayne State University. The findings also suggested how brains learn to multitask with age. The study was published in ‘Current Biology’.
Historically, a lack of high-resolution data from children’s brains has led to gaps in understanding how the developing brain formed memories. The study innovated the use of intracranial electroencephalogram (iEEG) on paediatric patients to examine how brain development supports memory development.
The scientists found a link between how the brains of people aged 5 to 21 were developing and how well they were able to form memories throughout that 16-year period. For example, younger children, whose brains were not as developed as the adolescent participants, weren’t able to form as many memories as some adolescents.
“Our study helps us actually explain how memory develops, not just that it develops,” said corresponding author Lisa Johnson, assistant professor of medical social sciences and paediatrics at Northwestern University Feinberg School of Medicine. “By understanding how something comes to be — memory, in this instance — it gives us windows into why it eventually falls apart.”
“Human memory develops throughout childhood, peaks in your 20s and, for most people, declines with age, even in those who don’t develop dementia.”
To address this, her work focused on the lifespan of memory to provide a holistic approach to understanding brain development and memory, which is why this study focused on paediatric patients.
The study focussed on communication between two regions of the brain that play a key role in supporting memory formation: the medial temporal lobe (MTL) and prefrontal cortex (PFC).
To learn how these regions talk to one another, the scientists analyzed two brain signals — a slowly oscillating brain wave and a faster oscillating one — that enable communication between regions. The rhythms dictated whether memory was successfully formed and differentiated top-performing adolescents from lower-performing adolescents and children.
The participants in the study were already undergoing brain surgery for another reason (usually to treat their epilepsy), and the scientists capitalized on this rare opportunity to examine data from electrodes placed directly on the exposed surface of the brain.
Following brain surgery, patients spent a week in the hospital for monitoring. This was when Johnson’s team conducted its studies, having the participants look at pictures of scenes to see how well they remembered them. The research team presented them with the same images again and new scenes they hadn’t yet seen (e.g., a different image of an outdoor area) to observe age-related differences in how well study participants remembered what they’d seen.
Another novel finding in the study was that there appeared to be age differences in fast and slow theta oscillations — rhythms in the brain that help with cognition, behaviour, learning and memory. The slow theta frequency slows down with age, and the fast get faster.
“These rhythms seemed to diverge with age so that they were similar in 5-year-olds and different in 20-year-olds,” Johnson said. “The fact that key memory regions are interacting at both frequencies suggests how your brain is learning to multitask as you get older.” (ANI)