Study: Head, neck cancer treatment can be improved by immunotherapy drug

Ohio [US], March 5 (ANI): By adding an immunotherapy drug to the standard of care treatment regimens, the survival rates for head and neck cancer patients with intermediate-risk features increased, suggests a recently conducted clinical trial by the University of Cincinnati.
The study was published in ‘Clinical Cancer Research’, a journal of the American Association for Cancer Research. The trial was led by Trisha Wise-Draper, MD, who was also the lead author of the study.
Wise-Draper said the trial focused on adding a drug, pembrolizumab, to patients’ typical standard care of treatments. Pembrolizumab, sold under the brand name Keytruda, is an antibody used in cancer immunotherapy that treats a variety of cancers, including head and neck. The drug targets a pair of receptors that usually work to turn off the human immune system when the immune system has finished a job of fighting off a foreign substance that causes sickness.
“Once the virus or infection is cleared, you have to have a way to turn your own immune system off, to tell it that the infection is gone and it’s time to calm down,” explained Wise-Draper, associate professor of medicine in the Division of Hematology/Oncology in UC’s College of Medicine, Head and Neck Center of Excellence co-leader, medical director of the University of Cincinnati Cancer Center Clinical Trials Office and Lab and a UC Health physician.
Tumour cells have learned to kick the receptors that shut the immune system off into overdrive, which blocks immune cells from recognizing that tumour cells are foreign objects that the body should attack. Pembrolizumab, however, blocks the interaction and keeps immune cells working, which in turn leads to the immune cells attacking cancerous cells like they are supposed to.
The drug has been developed as a treatment for multiple cancers, and Wise-Draper said that it has shown early success as a treatment for head and neck cancers that have spread or returned after initial treatment, with early studies reporting effectiveness for about 20 per cent of patients treated.
“And although we’re careful to say cure, it does result in what is called ‘durable responses,'” she said, explaining that means patients have a good response to treatment much longer than expected, sometimes for years, “which was a huge advancement over chemotherapy where they may have only been effective for say nine to 10 months at most,” Wise-Draper said.
With the early data looking promising, the UC clinical trial was seeking to find if the drug would work as an initial treatment that would prevent cancer from recurring. Patients with head and neck cancer — that are treated with the standard surgery, radiation, and potentially chemotherapy if risk factors warrant it — typically see the cancers return about 30 per cent-50 per cent of the time, Wise-Draper said.
“So instead of waiting for them to come back, could we try to prevent them from coming back? If cancer came back, they were much harder to cure the second time and had a lot of failure in that group,” she said. “So we asked if we could add this immunotherapy, the pembrolizumab, and decrease that risk of cancer coming back.”
Wise-Draper said the trial was also designed to examine why some patients respond to pembrolizumab while others do not. To accomplish this goal, tissue and blood samples were collected before and after administering the drug to analyze factors that contributed to patients responding to the treatment.
Patients enrolled in the trial were given one dose of the drug before surgery and were evaluated for risk status and grouped into intermediate- and high-risk groupings after surgery. A patient is considered high risk if part of the tumour is still left behind after surgery or is not contained in a lymph node.
All patients continued to receive the appropriate standard of care (radiation alone for intermediate-risk or radiation and chemotherapy for high risk), with six more doses of pembrolizumab also administered after surgery.
Wise-Draper said the drug caused tumours to begin to die before surgery in nearly 50 per cent of patients, a better rate than what was found when the drug was given for metastatic or recurrent head and neck cancer.
“We could see that a lot of these tumours were dying even after that first dose of pembrolizumab,” Wise-Draper said. “That was pretty exciting because that was higher than we expected.”
Less than 70 per cent of patients in the intermediate group who were treated with radiation alone after surgery was typically disease-free one year following treatment, but more than 95 per cent of patients in the trial reported one-year disease-free survival when treated with both radiation and pembrolizumab.
“We had a huge improvement in that, so we saw that pembrolizumab was definitely increasing their chance of survival, at least compared to historical controls,” Wise-Draper said.
In the group of patients where the drug began to kill the tumour prior to surgery, 100 per cent reported one-year disease-free survival.
“It was a really strong predictor of patients who are going to do well on this treatment,” Wise-Draper said. “Hopefully that is going to help us design trials to better understand who is going to respond and who is not.”
A reliable predictor for patients that will likely do well on the treatment will also help determine how treatments can be adjusted for patients who receive surgery, pembrolizumab, chemotherapy and radiation and do not respond well to the treatment.
“That’s really where the research is going now is trying to understand what are those biomarkers between the responders versus the non-responders and how we can develop new and better-targeted therapies,” Wise-Draper said. “We have a couple of identified markers that will help us going forward, but we’re still doing a lot of research in that area.”
Harvard University researchers have conducted a study similar to UC’s that showed similar success, and the successful findings of these trials show that a randomized Phase III clinical trial is worth pursuing. Pharmaceutical company Merck is in the process of conducting a randomized trial comparing patients who receive pembrolizumab in addition to their standard of care versus patients who receive the standard of care only.
“That will be a much larger study that will help show if pembrolizumab truly benefits these groups,” Wise-Draper said of the Merck study.
Research at UC into pembrolizumab as a head and neck cancer treatment is ongoing, with a next round of research being designed to learn how treatments can be more personalized to each patient. Tumour characteristics and biomarkers that can help predict whether a patient will respond to a certain treatment can be analyzed before surgery, with more specific treatment plans hopefully leading to better results.
“It’s been extremely exciting to see patients do well on this study and seeing their survival increase knowing what the historical rates were, as well as just being able to have a successful study, in general, is pretty exciting,” Wise-Draper said. “A lot of these developments I didn’t expect to happen so quickly in my career, so it’s really been an exciting process for all of us. Hopefully, there’s more to come.”
If the drug continues to prove safe and effective, Wise-Draper said it will mark a “huge improvement” compared to the current standard of care that can still lead to a 50 per cent recurrence rate. There is even a possibility that patients would not need their treatment plan to include surgery, she said.
“If we have a treatment that is less toxic, maybe we can cut down on the morbidity of surgery and radiation as well as the chemotherapy,” Wise-Draper said. (ANI)