Sunil Chhetri got off the mark this season for the Blues, and Javi Hernandez scored his third goal of the season but Bengaluru FC fell to their sixth defeat of the season.
The Blasters have won four of their past five ISL games, while the Blues have dropped five of their last six, so it will be a battle of contrasting teams. Kerala will look to continue its winning run while Bengaluru FC will look to return to winning ways.
Jorge Diaz and Lalengmawia Ralte scored in the first half, while Bipin Singh and Lallianzuala Chhangte sealed a comfortable 4-0 win for the Islanders in the second half.
After scoring heavily in their 6-2 come-from-behind win over Chennaiyin FC in their last game, Mumbai City FC have now scored 16 goals in six games, the highest in the ISL this season.
Nandhakumar Sekar scored a belter in the 33rd minute, and it turned out to be the game's only goal. This was Sekar's second ISL goal and also his second against Bengaluru FC in the ISL.
In both wins, Gombau's men came from behind to take full home points, but the head coach demanded his team to start scoring early on and keep the result instead of fighting for a late comeback.
The hosts clinched a crucial win against Kerala Blasters this past Sunday, while the visitors are coming into this game after a narrow loss in Hyderabad.
Roy Krishna scored inside five minutes to give the Blues an early advantage but Prasanth Karuthadathkuni scored at the stroke of half-time to restore parity.
Chennaiyin, making a much-awaited return to the city, will come into the match in high spirits after kickstarting their campaign in style, beating ATK Mohun Bagan 2-1 in the opening fixture earlier this week.