Using state-of-the-art whole-genome sequencing and machine learning techniques, researchers conducted one of the first and the largest investigations of tandem repeats in schizophrenia, elucidating their contribution to the development of this devastating disease.
More than a decade before people with Huntington's disease show symptoms, they can exhibit abnormally high levels of an immune-system molecule called interleukin-6 (IL-6), which has led many researchers to suspect IL-6 of promoting the eventual neurological devastation associated with the genetic condition. A new investigation by MIT neuroscientists shows that the story likely isn't so simple. In a new study they found that Huntington's model mice bred to lack IL-6 showed exacerbated symptoms compared to HD mice that still had it.
A team of researchers led by Swansea University have developed new technology to monitor cholesterol in brain tissue which could uncover its relation to neurodegenerative disease and pave the way for the development of new treatments.
Huntington's disease, a fatal, inherited neurodegenerative condition, is caused by a genetic error present at birth, though its symptoms often don't begin until middle adulthood. Scientists at Washington University School of Medicine in St. Louis have been trying to understand how the ageing process triggers the onset of symptoms, with the expectation that such knowledge could point to treatments that delay or prevent neurodegeneration.
Huntington's disease, a fatal, inherited neurodegenerative condition, is caused by a genetic error present at birth, though its symptoms often don't begin until middle adulthood. Scientists at Washington University School of Medicine in St. Louis have been trying to understand how the ageing process triggers the onset of symptoms, with the expectation that such knowledge could point to treatments that delay or prevent neurodegeneration.
New York [US], October 7 (ANI): Johnny Depp is soon going to take the centre stage in New York alongside Jeff Beck as a part of his North American tour which the duo kick-started last week.
Washington [US], September 30 (ANI): Researchers have used artificial intelligence to predict hospitalisation outcomes of geriatric patients with dementia on the first or second day of admission. Early outcome assessment means more timely interventions, better care coordination, more prudent resource allocation, focused care management, and timely treatment for these more vulnerable, high-risk patients.
Washington [US], September 19 (ANI): Huntington's disease is a genetic brain disorder caused by a mutation in the huntingtin gene. HD is a neurological disease that has no cure and produces personality changes, dementia symptoms, and uncontrollable convulsive movements, eventually leading to death. Such HD symptoms are known to be produced by the loss of brain cells in the striatum as a result of difficulties emerging in synapses that are critical to brain function during the disease's progression. However, the precise mechanism behind brain dysfunction during the course of HD is still unknown.
Seoul [South Korea], August 15 (ANI): An international research team has succeeded in recovering muscle movement in a model of paralysed mice organic through artificial nerves. The team was led by Prof. Tae-Woo Lee (Department of Materials Science and Engineering, Seoul National University, Republic of Korea) and Prof. Zhenan Bao (Department of Chemical Engineering, Stanford University, US).
San Diego (California) [US] August 2 (ANI): The body absorbs too much iron due to a condition known as hereditary hemochromatosis, which is brought on by a gene mutation. This causes tissue damage and diseases like liver disease, heart disease, and diabetes. However, scant and conflicting research had shown that the blood-brain barrier, a system of blood arteries and tissue made up of tightly spaced cells that guards against invasive pathogens and toxins, was responsible for sparing the brain from iron accumulation.
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