Chandipur (Odisha) [India], September 8 (ANI): India on Thursday successfully completed six flight tests of the Quick Reaction Surface to Air Missile (QRSAM) system off the Odisha Coast.

New Delhi [India], December 30 (ANI): Indian researchers have developed a high-performance industry-standard model for Aluminium gallium nitride (AlGaN/GaN) High Electron Mobility Transistors (HEMTs) with simple design procedures which can be used to make high-power Radio Frequency (RF) circuits owing to its high breakdown voltage, informed the Ministry of Science and Technology on Thursday.

Coimbatore Tamil Nadu India Business Wire India Rheumatological conditionsautoimmune diseases have been increasing at an alarming rate early detection can help arrest disease progression and prevent complications The Department of Rheumatology Clinical Immunology at Sri Ramakrishna Hospital provides an in-depth look into various rheumatological conditions and the signs to look for to make an early diagnosis Rheumatology is a subspeciality of medicine which involves the study of muscles tendons and joints Immunology deals with the immune system which is the first line of our bodys natural defence system It plays a vital role in safeguarding us from various illnesses affecting our bodies However when this immune system fails to function properly it leads to many autoimmune diseases Rheumatic diseases can affect any part of the body from head to toes It may start as simple as a fever or rash and these signs may only be the beginning of a serious underlying health problem Rheumatological conditions need to be diagnosed and treated at the earliest to avoid long-term complications including joint deformities and disabilities General awareness of rheumatology and immunology is necessary to make an early diagnosis and avoid unwanted long-term sequelae Rheumatoid arthritis The most common form of immune-mediated inflammatory arthritis is Rheumatoid Arthritis RA It generally affects the joints either on one side or both sides of the body This condition usually starts as joint pain swelling and stiffness and if left ignored it could progress to deformities and severe restriction in motion In addition RA can affect other parts of the body including the skin eyes lungs heart and kidneys Ankylosing spondylitis Ankylosing spondylitis AS is another form of immune-mediated inflammatory arthritis and is a type of seronegative arthritis AS typically affects adolescents and young adults causing back pain and stiffness more pronounced first thing in the morning and after prolonged rest It causes spine deformity and a stopped posture if left untreated AS also affects peripheral joints and cause extra-articular features commonly affecting eyes uveitis skin psoriasis and bowel inflammatory bowel disease Psoriatic arthritis and other Seronegative arthritis Psoriatic Arthritis PsA is another type of seronegative arthritis which occurs in one-third of patients with skin or scalp psoriasis It can occur even before or concurrently or after developing psoriasis There are also other types of seronegative arthritis such as Reactive Arthritis Spondyloarthropathy SpA and Enteropathic Arthritis arthritis due to ulcerative colitis and Crohns disease These conditions are collectively labelled as seronegative arthritis as the blood test for rheumatoid factor RF is negative They share many clinical radiological and genetic features different from RA Various traditional and contemporary treatments are available for RA AS PsA and other seronegative arthritis Conventional treatments are called disease-modifying anti-rheumatic drugs DMARDs and modern treatments are constantly evolving to target specific proteins Cytokines which perpetuate the disease process These modern drugs are called Targeted Therapies and Biologics which have revolutionized the treatment of arthritis These contemporary treatments are in the form of tablets injections and infusions Gout and Pseudogout Gout is the most common form of Inflammatory Monoarthritis arthritis affecting a single joint and the great toe is the most common joint affected It causes sudden onset of excruciating joint pain associated with swelling redness and heat It is due to a buildup of high uric acid levels in the body with the deposition of uric acid crystals in the affected joint It is generally due to the high intake of a purine-rich high protein diet Alcohol is another common risk factor for gout and lifestyle modifications including reducing weight increasing physical activities adequate hydration and avoiding a high purine diet and alcohol are crucial in the treatment and prevention of gout Pseudogout is another form of crystal arthritis that mimics gout and it is usually secondary to certain medical conditions and not due to dietary risk factors Connective tissue diseases and Vasculitis Connective Tissue Diseases CTD and vasculitis are also common rheumatological conditions and the examples include Lupus SLE Sjogrens syndrome Scleroderma Mixed Connective Tissue Disorder MCTD and Myositis They can cause many symptoms affecting various organs with or without Arthritis so patients with these conditions may present to different specialists with diverse symptoms It is crucial to diagnose these conditions very early and treat them aggressively to prevent major organ or life-threatening complications Modern treatments including biologics are now available to effectively manage these once dreadful conditions Osteoporosis As the name implies this condition leads the bones to become porous and weakens the bone to a great extent resulting in a fracture Osteoporosis is aptly called a silent disease as the condition may go unnoticed for a long time and the first presentation may be a fracture without any trauma It is most common in post-menopausal women but it can affect young women and men due to some risk factors It can be effectively treated using both conventional and modern drugs in the form of tablets subcutaneous injections and intravenous infusions Juvenile Idiopathic Arthritis JIA and other childhood rheumatological conditions JIA is similar to the adult form of immune-mediated inflammatory arthritis such as RA AS and PsA that occurs in children aged 16 or younger Treatment for JIA are similar to the adult form of arthritis and they include DMARDs targeted therapies and biologics A child needs to be diagnosed at the earliest and treated intensively to prevent irreversible joint damage and other unwanted long-term sequelae Periodic Fever Syndromes PFS or Systemic Autoinflammatory Disorders SAID are other rare forms of childhood rheumatological conditions that commonly present with fever and rash with or without arthritis These conditions require careful evaluation and management by experts with modern treatments to stop disease progression and prevent complications About The Department of Rheumatology Clinical Immunology The Rheumatology Clinical Immunology Department at Sri Ramakrishna Hospital has an experienced rheumatology team In addition it has close links with other medical and surgical specialities including allied therapies such as physiotherapy and orthotics to provide an efficient multidisciplinary service It has full-fledged laboratory facilities including immunology biochemistry microbiology haematology and histopathology which assist in making a precise diagnosis and starting appropriate treatment as early as possible Sri Ramakrishna Hospital httpswwwsriramakrishnahospitalcom also has an excellent radiology nuclear medicine department with state-of-the-art imaging facilities including musculoskeletal ultrasound US MRI CT HRCT x-rays bone mineral density BMDDEXA whole body as well as three-phase isotope bone scan and PET-CT About Sri Ramakrishna Hospital Sri Ramakrishna Hospital has attained an iconic reputation since its inception in 1975 Situated right in the heart of Coimbatore city this hospital has in many ways become a part of medical history In fact it has been an integral part of the healthcare revolution of modern India Established and run by the SNR Sons Charitable Trust Sri Ramakrishna Hospital treats thousands upon thousands of patients each year From the most advanced procedures to treatments for everyday ailments they bring relief to patients from all walks of life using state-of-the-art technology and cutting-edge surgical and medical techniques to deliver outstanding outcomes httpswwwyoutubecomcSriRamakrishnaHospital httpswwwfacebookcomSriRamakrishnaHospital httpswwwinstagramcomramakrishnahospital 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Coimbatore (Tamil Nadu), December 29 (ANI/BusinessWire India): Rheumatological conditions/autoimmune diseases have been increasing at an alarming rate, early detection can help arrest disease progression and prevent complications.